منابع مشابه
Anthrax, but Not Bacillus anthracis?
B acillus anthracis, the etiologic agent of anthrax, is a close relative of B. cereus, a soil organism and known opportunistic pathogen that causes a variety of human infections [1]. B. anthracis is very similar to B. cereus and B. thuringiensis except that all confirmed samples of B. anthracis suggest that it is a monophyletic clone derived from the B. cereus and B. thuringiensis clade. The ma...
متن کاملAnthrax: Biology of Bacillus anthracis
Perhaps no other microorganism has received as much attention for its use as a potential agent for bioterrorism as Bacillus anthracis. In spite of the fact that the organism has been known for a very long time, limited progress has been made in developing a vaccine or understanding its biochemical and genetic properties. The genus Bacillus includes aerobic bacilli forming heatresistant spores. ...
متن کاملDendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.
Phagocytosis of inhaled Bacillus anthracis spores and subsequent trafficking to lymph nodes are decisive events in the progression of inhalational anthrax because they initiate germination and dissemination of spores. Found in high frequency throughout the respiratory track, dendritic cells (DCs) routinely take up foreign particles and migrate to lymph nodes. However, the participation of DCs i...
متن کاملStability and potency studies of anthrax vaccine (Bacillus anthracis 34F2 Sterne strain) in Iran
For evaluation the stability and potency of anthrax vaccine prepared in Razi Vaccine and Serum Research Institute in Iran, samples of different batches of vaccine were kept at 4-8 °C (refrigerator), 20-25 °C (room temperature) and 37 °C (incubator).The viable spores/ml of vaccines were determined using plate–counting method before and after holding at different temperatures monthly. Vaccine p...
متن کاملRegulation of anthrax toxin activator gene (atxA) expression in Bacillus anthracis: temperature, not CO2/bicarbonate, affects AtxA synthesis.
Anthrax toxin gene expression in Bacillus anthracis is dependent on the presence of atxA, a trans-acting regulatory gene located on the resident 185-kb plasmid pXO1. In atxA+ strains, expression of the toxin genes (pag, lef, and cya) is enhanced by two physiologically significant signals: elevated CO2/bicarbonate and temperature. To determine whether increased toxin gene expression in response ...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2006
ISSN: 1553-7366,1553-7374
DOI: 10.1371/journal.ppat.0020122